Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
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Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.
Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express both cyclins, which bind to and activate p34(cdc2). To test whether the two B-type cyclins have distinct roles, we generated lines of transgenic mice, one lacking cyclin B1 and the other lacking cyclin B2. Cyclin B1 proved to be an essential gene; no homozygous B1-null pups were born. In contrast, nulliz...
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COHIRO Biotechnology, Faculty of Medicine, 21000 Dijon France (http://www.cohiro.fr/), Laboratory of Cardio-Metabolic Pathophysiology and Pharmacology (LPPCM), INSERM, U866 , Université de Bourgogne, 21000 Dijon, France, Department of Cardiology, University Hospital, Dijon (21000), France , Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM, U1048, Université Paul Sabatier, 31432...
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In contrast to cyclin D1 nulls (cD1-/-), mice without cyclin D2 (cD2-/-) lack cerebellar stellate interneurons; the reason for this is unknown. In the present study in cortex, we found a disproportionate loss of parvalbumin (PV) interneurons in cD2-/- mice. This selective reduction in PV subtypes was associated with reduced frequency of GABA-mediated inhibitory postsynaptic currents in pyramida...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.8.4344